Thursday, April 23, 2015

Part 2: Chapters 10-19 Question 32

What is “extreme amplification”?

3 comments:

  1. Extreme amplification is the multiplication of a virus in the body of the host or a population of hosts. When Nancy took a look at the slides that contained slices of liver from monkeys that had died in the monkey house, she saw “[how] the terrain was a mess” (Preston 146). The cells weren’t the same, like if something had ravaged them. The liver looked like if it was carpet-bombed. She also saw dark blobs in the cell as well. She also saw crystalloids, which are substances that can pass through a semipermeable membrane and be crystallized. They are different from bricks because bricks do not look like crystals. Ebola bricks come in many shapes (blobs, lumps, rings). Some of these cells consisted of single bricks and even bricks that have grown so fat as well. When extreme amplification has occurred, the virus can be seen with the human eye as tarry black granules. They thought that the Ebola virus might of spread in Zaire through dirty needles at the monkey house. Furthermore, during extreme amplification, the virus spreads its replicated copies allowing an event of deadly transmissions, which could ultimately threaten a certain population ( i.e. United States) and the world if it turns into a major outbreak and is not controlled.

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    1. As Lesley mentioned, extreme amplification is considered as the production of viruses. On the other hand, there is more to this definition which is actually responsible for making the term so negative. Extreme amplification involves the production of viruses, but in huge quantities. The viruses basically take over the entire host, from head to toe. There is no region of the organism that hasn’t been infected with the virus. The concentration of viruses grows exponentially, and the virus is ultimately leaving the host with no cells of its own. The host dies before it becomes completely infested with viruses, so the virus moves onto another host, and the entire cycle repeats itself again (Preston, 1994, pg.14).

      Preston, R. (1994). The Hot Zone. New York: Random House.

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    2. Hi Lesley, are there any other viruses that produce by extreme amplification other than Marburg and Ebola?

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