Thursday, April 23, 2015

Part 2: Chapters 10-19 Question 15

What are bricks and why are they so dangerous?

4 comments:

  1. Bricks are crystalloids. The crystalloids are the blocks of virus known as the inclusion bodies. They are dangerous because the moment the brick has contact with the cell wall the viruses burst out of the cell. The bricks change the cell shape like how the cell was altered in Dan's experiment. The cell changes in shape, bursts, and kills the cell (Preston, 1994) The viruses travel through the host's bloodstream to infect other cells. Like a cascade the virus are reproduced and burst out of the cells in huge powerful numbers to go on with more infection. If the infection goes on then the host will die unless the host's immune system can work quickly to get rid of the virus (NPR, 2009). If the immune system fails it is because the virus was able to mutate or make the immune system believe that the virus isn't foreign. The virus could modify the ligand for antibodies and T cell receptors, be dormant or have viral proteins interferons, cytokines and chemokines stopped or mimicked (Simmons, Willberg, and Paul , 2013).
    This is like the lytic cycle where the virus replicates to burst out of the cell, killing the host. The lytic cycle doesn't form a brick, or there is nothing that says otherwise (Two Life Cycles of a Virus, n.d.).

    Simmons, Willberg, Paul, R. (2013, June 1). Immune Evasion by Viruses. Retrieved May 17, 2015, from http://www.els.net/WileyCDA/ElsArticle/refId-a0024790.html

    Flu Attack! How A Virus Invades Your Body. (2009, October 23). Retrieved May 17, 2015, from https://www.youtube.com/watch?v=Rpj0emEGShQ

    2 Life Cycles of a Virus. (n.d.). Retrieved May 17, 2015, from http://biology.kenyon.edu/HHMI/Biol113/2virus.htm

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    Replies
    1. The bricks are the crystals of clumped up ebola viral cells. The reason they are dangerous isn't because they'll make the cell burst, but because they already made the cell burst (Preston 183). Their rapid exponential reproduction eventually and quickly fills up the cells to the point where they basically become "pregnant" (Preston 183). The essentially give birth to the viral cells, dying in the process. These viral cells then float off among the rest of the cells, easily infecting the other cells because they were able to disguise themselves with the host's membrane proteins. The process is repeated, with the viral cells penetrating the host cell, reproducing to the point of bursting and killing the host cell, and searching for a new victim. Their danger mainly lies in its high density of infectious material.

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    2. The bricks are the crystals of clumped up ebola viral cells. The reason they are dangerous isn't because they'll make the cell burst, but because they already made the cell burst (Preston 183). Their rapid exponential reproduction eventually and quickly fills up the cells to the point where they basically become "pregnant" (Preston 183). The essentially give birth to the viral cells, dying in the process. These viral cells then float off among the rest of the cells, easily infecting the other cells because they were able to disguise themselves with the host's membrane proteins. The process is repeated, with the viral cells penetrating the host cell, reproducing to the point of bursting and killing the host cell, and searching for a new victim. Their danger mainly lies in its high density of infectious material.

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    3. Hi Helen, what specifically on the Ebola virus allows for it to enter human cells?

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